Ense Workshop: Prof. Cristian Picioreanu

Jul 21 2019 09:00 AM - Jul 25 2019 05:00 PM


Advanced Modeling in Biochemical Engineering and Environmental Biotechnology

By Prof. Cristian Picioreanu, Associate Professor, Environmental Biotechnology at TUDelft


Date: July 21 – 25, 2019

Time: 9:00 am – 5:00 pm

Venue: Library, level 3, Computer Lab-3134

*Refreshments and light lunch will be provided.


The course combines the basic theory of modelling bioprocesses in environmental and biochemical engineering with practical tutorials and hands-on experience on computer-based applications. The course makes extensive use of simulation software such as COMSOL Multiphysics.  Activated sludge and anaerobic digestion models will be integrated in diverse bioreactor types and operation modes. Several modern bioprocesses using microbial biofilms will be investigated.  A step-by-step modelling approach is followed, from simple lumped models to 1-D, 2-D and 3-D, stationary and time-dependent systems.  

OPTIONAL: The students will have to pass a final two-hours test developing and solving a model with computer aid.

The five-day course consists of:
  • Lectures (1-2h, daily) with interactive discussion and questions
  • Computer simulation practice (5-6h, daily) with COMSOL Multiphysics


  • Conservation equations and basic reactor operation models (batch, repeated fed-batch, continuous stirred tank and plug-flow)
  • Reaction models:    activated sludge (ASM1, ASM2d) and anaerobic digestion (ADM1)
  • Biomass immobilization, biofilms, flocs and granules. One-, two-, three-dimensional biofilm modeling. (models for solute transport and reaction, biomass dynamics and biofilm development)
  • Examples from nitrification, phototrophic and dental plaque microbial processes
  • Fixed bed,  step-by-step modelling.  Membrane biofilm reactors. 

The seats are limited to 20 participants.